cDNA Cloning of Human Apo-E and Analysis of the Apo-E Gene in a Patient with Apo-E Absence
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چکیده
منابع مشابه
Apo A-i and Apo E Interaction: beyond Lipoproteins
Apolipoproteins (Apo) A-I, A-II, A-IV, and E possess repeated amphipathic helical regions with the same genomic structure and are members of a multigene family that probably evolved from a common ancestral gene [1]. These apolipoproteins play pivotal roles in lipid transport and lipoprotein metabolism, and their carboxyl-terminal domain is critical for lipid binding [2]. The purpose of this com...
متن کاملEffect of Chronic Hypo - and Hyperthyroidism on Apo A - I , Apo E , and Albumin mRNAAbundance and Apo A - I Gene Transcription in Rat Liver
To study the regulation of hepatic apo A-I gene expression, we measured synthesis and abundance of cellular apo A-I mRNA and its nuclear precursors in livers of hypothyroid and hyperthyroid rats. In hypothyroid animals, both synthesis and abundance of apo A-I mRNA was reduced to half of control values. After injection of a receptor-saturating dose of triiodothyronine into euthyroid rats, apo A-...
متن کاملTwo independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.
We have reported previously that canine livers possess two distinct lipoprotein receptors, an apoprotein (apo)-B,E receptor capable of binding the apo-B-containing low density lipoproteins (LDL) and the apo-E-containing cholesterol-induced high density lipoproteins (HDLc), and an apo-E receptor capable of binding apo-E HDLc but not LDL. Both the apo-B,E and apo-E receptors were found on the liv...
متن کاملHepatic apo-A-I and apo-E and intestinal apo-A-I are synthesized in precursor isoprotein forms by organ cultures of human fetal tissues.
In this report, we demonstrate that organ cultures of human fetal liver and intestine synthesize and secrete into the culture medium the major apolipoproteins. The liver cultures were shown to produce apo-A-I, apo-A11, apo-B, apo-C-11, apo-C-IIIs, and apo-E, and the cultures of intestine produced primarily apo-A-I. The synthesized apolipoproteins secreted into the culture medium were identified...
متن کاملReview: Apolipoprotein E (Apo E) gene polymorphism and coronary heart disease in Asian populations.
Apolipoprotein E (Apo E) is a basic component of very low-density lipoprotein (VLDL) and high-density lipoprotein (HDL). It plays an important role in the clearance of cholesterol from circulation, and thereby slows down the process of atherosclerosis. Its 3 isoforms, E2, E3 and E4 are encoded by 3 alleles, e2, e3 and e4, respectively. E3 is the most common isoform in most populations in the wo...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1985
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.13.4_843